NAD+

Nicotinamide adenine dinucleotide (NAD+) is a dinucleotide coenzyme present in every living cell, serving as an indispensable electron carrier across hundreds of redox reactions in glycolysis, the citric acid cycle, and oxidative phosphorylation. Its role extends beyond metabolism: NAD+ is consumed as a substrate by sirtuins (class III histone deacetylases governing gene expression and stress responses), poly-ADP-ribose polymerases (PARPs critical to DNA repair), and CD38/CD157 glycohydrolases — enzymes collectively central to cellular maintenance and aging biology.

Tissue NAD+ concentrations decline measurably with age, a phenomenon now considered a hallmark of metabolic aging. This decline is associated with impaired mitochondrial function, reduced sirtuin activity, compromised DNA repair capacity, and increased susceptibility to metabolic disease. Parenteral NAD+ administration — intravenous and subcutaneous — is studied as a direct strategy to elevate tissue levels beyond what oral precursor supplementation achieves.

ROEHN provides NAD+ at 99% HPLC-verified purity as a lyophilized powder. Research protocols have examined its effects on bioenergetics, cognitive function, metabolic biomarkers, and cellular senescence endpoints, establishing it as one of the most actively investigated molecules in the longevity research landscape.